While fibrin is a biological sealant that has been harnessed by several companies to provide tissue sealing, a wide variety of other components and component combinations have been developed for sealant use.
Below are sealant formulations from selected participants in the market for surgical sealants:
Sealant Components by Manufacturer
| Company | Sealant component(s) |
|---|---|
| Adhesys | Polyurethane |
| Cohera | Urethane & lysine |
| Endomedix | Dextran and chitosan biopolymers |
| Gecko Biomedical | Proprietary, light-activated, synthetic elastomer |
| Grifols | Fibrin sealant |
| Baxter | Human fibrinogen and thrombin |
| Ethicon | Fibrin sealant |
| Bard | Hydrogel |
| Takeda | Fibrin sealant |
| The Medicines Company | Fibrin sealant, and synthetic sealant |
| CryoLife | Bovine serum albumin and glutaraldehyde adhesive |
| Hyperbranch | Activated polyethylene glycol polyethlyeneimine |
| Integra Lifescience | Polyethylene glycol hydrogel |
| LifeBond | Polymer hydrogel matrix |
| Ocular Therapeutix | Polyethylene glycol and trilysine |
| Sealantis | Alga-mimetic tissue adhesives |
Source: MedMarket Diligence, LLC; Report #S290.