While fibrin is a biological sealant that has been harnessed by several companies to provide tissue sealing, a wide variety of other components and component combinations have been developed for sealant use.
Below are sealant formulations from selected participants in the market for surgical sealants:
Sealant Components by Manufacturer
|Cohera||Urethane & lysine|
|Endomedix||Dextran and chitosan biopolymers|
|Gecko Biomedical||Proprietary, light-activated, synthetic elastomer|
|Baxter||Human fibrinogen and thrombin|
|The Medicines Company||Fibrin sealant, and synthetic sealant|
|CryoLife||Bovine serum albumin and glutaraldehyde adhesive|
|Hyperbranch||Activated polyethylene glycol polyethlyeneimine|
|Integra Lifescience||Polyethylene glycol hydrogel|
|LifeBond||Polymer hydrogel matrix|
|Ocular Therapeutix||Polyethylene glycol and trilysine|
|Sealantis||Alga-mimetic tissue adhesives|
Source: MedMarket Diligence, LLC; Report #S290.