Tag Archives: surgical glue

Opportunities for med/surg sealants, glues, hemostats driven by type of clinical benefit, competition

Advanced products for the closure, sealing, hemostasis and other endpoints for medical and surgical wounds generate varying degrees of clinical benefit based on the manner and extent to which they enable management of different wound types.  Degrees range from the acute need end of “important and enabling” to the less clinically necessary “aesthetic and perceived benefits”:

  • Important and enabling: Important to prevent excessive bleeding and transfusion, to ensure safe procedure, and to avoid mortality and to avoid complications associated with excessive bleeding and loss of blood.
  • Improved clinical outcome: Reduces morbidity due to improved procedure, reduced surgery time, and prevention of complications such as fibrosis, post-surgical adhesion formation, and infection (includes adjunct to minimally invasive surgery).
  • Cost-effective and time-saving: Immediate reduction in surgical treatment time and follow-up treatments.
  • Aesthetic and perceived benefits: Selection is driven by aesthetic and perceived benefits, resulting in one product being favored over a number of medically equivalent treatments.

These benefits are clearly different on a clinical specialty-by-specialty basis.  The numbers of targeted or prospective procedures also vary considerably by specialty. As a result, wound closure and securement products have the following categorized potential use worldwide:

Source: “Surgical Procedures with Potential for the Use of Hemostats, Sealants, Glues and Adhesion Prevention Products, Worldwide “; Report #S190.


Surgical sealants, glues, sutures/clips, hemostats outside the U.S.

See the updated, published 2012 Report #S190, “Surgical Sealants, Glues, Sutures, Other Wound Closure and Anti-Adhesion, Worldwide Markets, 2012-2017.”

The world market for the securement products, encompassing wound closure/sealing, hemostasis and anti-adhesion) is currently valued at more than $9.7 billion. This total market is growing at a steady 6.7% compound annual rate, though growth rates for individual regions vary.

Average growth in the world closure and securement products market also reflects differing conditions in individual countries, ranging between 3% CAGR for less developed economies and considerably higher for the United States.

Below is illustrated the market value and compound annual growth rate of the closure and securement market for countries outside the U.S. (the U.S. dominates the world market, largely dwarfing non-U.S. markets).

 

Securement-size-growth

 

Source: MedMarket Diligence Report #S180; “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015.”

Posted via email from medmarket’s posterous

Steady growth in wound management products

Wound management, with its diverse products, well established base and growth prospects, not only for the advanced product segments but also for its tradiitional products, is an attractive area for medical technologies, drawing many active market participants.

The need for effective and improved technologies for acute and chronic wounds continues to be high, driven by the demographics of the aging population, the increasing sensitivity of healthcare systems to high costs such as chronic wounds and other forces.  The industry has responded by developing and introducing more complex types of wound products focused on shortening wound healing times and costs.

The largest single category of wound management products is already in physical wound management, encompassing negative pressure wound therapy, hyperbaric oxygen, hydrotherapy, electrical stimulation, electromagnetic stimulation, ultrasound, laser and others.  This category will also demonstrate some of greatest growth in wound management over the next several years. Other areas of significant growth include the use of growth factors, and foam and alginate dressings.

Illustrated is the global wound management market by product segment for 2008 and 2017.

Wound-by-segment-2008-2017

Source: MedMarket Diligence, LLC; Report #S247.

Posted via email from medmarket’s posterous

Sealants and adhesives on course to seize the wound closure pie

See the updated, published 2012 Report #S190, “Surgical Sealants, Glues, Sutures, Other Wound Closure and Anti-Adhesion, Worldwide Markets, 2012-2017.”

One of the hallmarks of the market for surgical sealants, glues and adhesives is that these products are steadily gaining greater and greater share of a market — medical and surgical wound closure — that is itself growing at a steady rate.

Barriers to entry to this market are not significant for medical products.  The products are biological, chemical and combinations of both, and may include syringes, dual mixing vials (for product activation) and other delivery devices.  Therefore, there has been a steady stream of market entrants over the past few years, a trend that we expect will continue.

Worldwide Shares of Wound Closure Market by Type, 2010 and 2015

Sealants-closure-pies

Source: Report #S180

In the 2010 and 2015 breakdown of the “wound closure” market (see side-by-side pie charts), one can consider that fibrin and other sealants plus high strength medical adhesives potentially might target the entire pie, gaining full share of the market that is held by both mechanical closures and staples and sutures.  In reality, sealants and adhesives are unlikely to fully displace use of sutures, staples and other traditional products in wound closure, but may capture a great majority of the caseload.  Furthermore, many closures using sutures, staples and clips procedures that remain may call for the adjunctive use of sealants and adhesives to ensure tighter seal of the wound, hasten tissue healing and provide other benefits.


For more details of this market, see MedMarket Diligence Report #S180: “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015.”

Posted via email from medmarket’s posterous


Until September 30, 2011, get any MedMarket Diligence report (any option: single user, site license or global license) for 20% off.  Order online (or any “online order” link) and use coupon code 1315780157 on checkout to receive a 20% discount.

Sutures, staples, clips and other wound closure still active in development

See the updated, published 2012 Report #S190, “Surgical Sealants, Glues, Sutures, Other Wound Closure and Anti-Adhesion, Worldwide Markets, 2012-2017.”

In our analyses of the market for surgical sealant, glues, wound closure, hemostasis and ant-adhesion products (Report #S180), we highlight that a major force in the development of these new products is in manufacturers driving innovation to enable the products to displace traditional wound closure products, especially sutures, staples and clips.

Given the size of this “mechanical closure” market, at over $5 billion annually, manufacturers in this space are not idly standing by while novel wound closure technologies poach their caseload.  A healthy number of companies are actively developing and marketing novel wound closure products that still fall in this traditional category of wound closure:

Source: MedMarket Diligence, LLC; Report #S180.

 

Companies represented here (many involved in development of multiple wound closure product types) include: 3M, Abbott Vascular, Angiotech Pharmaceuticals, ArthroCare , B. Braun/Aesculap, BSN Medical, Cardiva Medical, Covidien, CSMG Technologies (Live Tissue Connect), Incisive Surgical, Innovasa, Johnson & Johnson (Ethicon), Kinetic Concepts, Morris Innovative, NeatStitch, Resorba, St. Jude Medical, Synovis Life Technologies, Teleflex Medical, Wound Care Technologies, and Zimmer.

This does not include the companies active in the area of medical/surgical tapes in a range of types; fabric, film, island, bandage, impregnated and others.

High Strength Medical and Surgical Glues

See the updated, published 2012 Report #S190, “Surgical Sealants, Glues, Sutures, Other Wound Closure and Anti-Adhesion, Worldwide Markets, 2012-2017.”

Cyanoacrylate products are the main form of high-strength surgical glue that is approved for human clinical use in the worldwide market. A number of new materials are under development for internal use in particular, but these represent new chemical entities and their commercialization is likely to be delayed by regulatory requirements.  While sutures will be replaced by cyanoacrylate glues in many procedures over the next 10 years, this will only occur after some technical challenges are overcome. For example, cyanoacrylate glues used for external skin closure are approximately five times less strong than sutures, and cyanoacrylates produce cytotoxic compounds as part of the curing process when used for securing torn or excised tissue. This has delayed the development and clinical evaluation of these potentially useful materials for internal surgical procedures. However, cyanoacrylate glues are marketed actively by a number of companies for topical wound closure in accident/emergency situations and in surgical closure.

Given the current size of the global market for high strength glues (at over $700 million) and the potential for this market to expand as products overcome the challenges of strength and toxicity, a respectable number of competitors compete in this space and many are working on further developing cyanoacrylate-based and other high strength adhesives (including fibrin-based and other “bio-glues”) to not only garner greater share of the existing market but to also erode the market for sutures and other mechanical wound closure products (e.g., clips and staples).

Source: MedMarket Diligence Report #S180, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2010-2015.”

Ethicon (J&J), Covidien and B. Braun (Aesculap) hold the major positions in the market for high strength medical and surgical adhesives, but their positions are at risk, and will continue to be at risk, as long as the unmet need exists for stronger, more compatible glues.  Some of the many products on the market and in development in the area of high strength glues include SurgiSeal, DermaSeal, FloraGuard, LiquiBand, SkinLink, Histoacryl, Gluetiss, Autologous biological glue, Chemence USP Class VI adhesives, TissueGlu, Indermil, Glubran2, Glubran Tiss, GluSeal, GluSite, PeriAcryl, GluShield, Dermabond, InteguSeal, Epiglu, Surgical Tissue Sealants (STS) and others.

Report: Surgical Sealants, Glues, Wound Closure and Anti-adhesion Worldwide

MedMarket Diligence (MMD) has published its 2010 report on the worldwide market for surgical sealants and related products in surgical and traumatic wound management.

The analysis by MMD reveals the size of the evolving opportunity for a diverse set of products in global markets. Based on extensive primary and secondary research, and leveraging MMD’s position as the leading source for the medtech industry on the subject, the report provides industry participants and hopefuls with invaluable data and insights.

The report is described below and at link

This report details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments in this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a market and technology assessment and forecast of surgical sealants, glues, hemostasis, other wound closure and anti-adhesion. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent surgical adhesions. The report provides a worldwide historic (from 2008), current and annual forecast to 2015 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade.  The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan, Korea and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a five-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

See link for complete table of contents and list of exhibits.  The report may be ordered for immediate download from link.