Naturally sticky: Biologically-based medical glues dominate

Medical glues are either biologically-based, cyanoacrylate, or other synthetic. The bulk of global sales of medical glues are biologically-based, (includes fibrin, thrombogen, and others), cyanoacrylate-based glues, and other synthetic glues.

Cyanoacrylate-based glues, include those from Ethicon, Adhezion Biomedical, B. Braun, Meyer-Haake, and others. Cyanoacrylates provide strong adhesion, but biologically-based glues have found more applications, both topically and internally. “Other” glues are of a variety of synthetic types; these glues have yet to gain more than 4% share globally.

Below is illustrated the growth of biologically-based glues by region, showing that most growth in this segment will be from Asia/Pacific markets, which are consistently demonstrating higher growth than in western markets.

Global Markets for Biologically-Based Medical Glues, 2015-2022, USD MillionsSource: MedMarket Diligence, LLC; Report #S290. (Order online)

 

Components used in surgical sealants

While fibrin is a biological sealant that has been harnessed by several companies to provide tissue sealing, a wide variety of other components and component combinations have been developed for sealant use.

Below are sealant formulations from selected participants in the market for surgical sealants:

Sealant Components by Manufacturer

CompanySealant component(s)
AdhesysPolyurethane
CoheraUrethane & lysine
EndomedixDextran and chitosan biopolymers
Gecko BiomedicalProprietary, light-activated, synthetic elastomer
GrifolsFibrin sealant
BaxterHuman fibrinogen and thrombin
EthiconFibrin sealant
BardHydrogel
TakedaFibrin sealant
The Medicines CompanyFibrin sealant, and synthetic sealant
CryoLifeBovine serum albumin and glutaraldehyde adhesive
HyperbranchActivated polyethylene glycol polyethlyeneimine
Integra LifesciencePolyethylene glycol hydrogel
LifeBondPolymer hydrogel matrix
Ocular TherapeutixPolyethylene glycol and trilysine
SealantisAlga-mimetic tissue adhesives

Source: MedMarket Diligence, LLC; Report #S290.