Category Archives: medtech

topic is about medical technology of different types, describing specific products under development, the market for them or their impact on healthcare

Technologies at startups identified in 2013 (through April)

Below is a list of the technologies at startup companies identified thus far in 2013 and included in the Medtech Startups Database:

  • Surgical tools for arthroscopic procedures.
  • Fractional flow reserve guidewire method to obtain FFR measurements during coronary catheterization procedures.
  • Technology to ensure accurate intraoperative placement of hip and knee implants.
  • Neurological diagnostics to measure biomarkers, regulate drug dosage, others.
  • Respiratory monitoring devices, such as a “sleep sensors” shirt to enable less invasive monitoring for apnea or other respiratory conditions.
  • Endoscopic, minimally-invasive harvesting of veins used for coronary artery bypass grafting.
  • Ophthalmology diagnostics; binocular device for eye exams.
  • Device-based treatment for respiratory disease.
  • Undisclosed ophthalmology technology.
  • Catheter-based medical devices for the treatment of cardiovascular disease
  • Extracorporeal rotary blood pump system designed to increase eligibility for the arteriovenous fistula (AVF) vascular access site for hemodialysis and to increase AVF maturation success.
  • Organ-specific stem and progenitor cells for use in research and therapeutic application, including stem cell transplants for lymphoma and leukemia.
  • Egg precursor cells for the treatment of infertility.
  • Polymer-based adhesive tissue tape for use as a surgical sealant.
  • Devices that are visible yet safe in radiofrequency and magnetic resonance fields.
  • Tissue removal device for removal of soft and hard tissue in orthopedics.
  • Laser-based detection of metastatic cancer cells.
  • Ultrasound therapeutics.
  • Detection of concussion.
  • Orthopaedic implants
  • Spine surgery implants including interspinous process spacers.
  • Technologies in ophthalmology.
  • Surgical implants including for hernia repair.
  • Stomal management solutions.
  • Ophthalmic drug delivery
  • Device for the treatment of fecal impaction.

Source: MedMarket Diligence, LLC

Wound prevalence by types, worldwide

The bulk of wound types driving the use of products for wound sealing, closure, hemostasis and anti-adhesion are surgical incisions made for the purpose of treating disease. While this figure is over 100 million annually on a global basis, its significance as a force for the use of wound closure and related technologies must be tempered by the fact that surgical incisions are intentionally made and therefore are made by surgeons and other clinicians with advanced expectation of how the wound will be closed.  By contrast, wounds of other types offer a degree of complexity and unpredictability that, even in their lower numbers, represent a markedly bigger challenge for clinicians to manage.  Indeed, the most significant costs in wound management ensue from chronic wounds, which arise as a result of inadequate circulation, excess pressure, infection, complicating disease or conditions (e.g., diabetes, obesity) and other factors.

Below is illustrated the global distribution of wound prevalence by type of wound (2011).


Source: MedMarket Diligence, LLC; Report #S190 and Report #S249.

Types and Uses of Wound Care Products

Wound care products take many forms based on the type of function provided by the product, the wound type and its severity.  Excluding for the moment the emerging array of physical wound healing systems (e.g., NPWT, hyperbaric oxygen, etc.), there are quite a number of combinations, and as new materials emerge, such as types of media or means to deliver wound care, the combinations are expected to multiply.

Below is illustrated a representation of wound product types, forms and applications.  This now includes the rapidly growing field of growth factors in wound care, which may be delivered by many different methods, including carrier or media types.

Types and Uses of Wound Care Products


Sources: Murphy, P.S. et al. Plastic Surgery International Volume 2012 (2012), Article ID 190436, 8 pagesdoi:10.1155/2012/190436; MedMarket Diligence, LLC, Report #S249.

Medtech fundings for April 2013

Fundings for medical technology during April 2013 totaled $422 million. Top fundings included:

  • $40 million for electroCore Medical, LLC (non-invasive vagal nerve stimulation therapeutic devices)
  • $39.3 million for Celator Pharmaceuticals (nanoparticle-based drug delivery in cancer)
  • $33 million for Esperion Therapeutics (LDL-lowering therapies)
  • $32.2 million for Watermark Medical, Inc. (sleep apnea diagnostics)
  • $29 million for Vaportherm (treatment for COPD, other respiratory)
  • $25.5 million for Solta Medical (medical aesthetics)
  • $25 million for Topera, Inc. (electrophysiology mapping systems)
  • $22.6 million in an IPO for InspireMD (vascular stents)
  • $20 million for Avinger (intravascular imaging)

For the complete list of fundings for April 2013 see link.

Growth versus current share in global wound management products

Sales of products in global markets for wound management are in a fairly dynamic state of flux, especially for the very large, well established market that it is.  Traditional wound management products — dressings and bandages that do little more than keep debris out of wounds — are being challenged aggressively by products playing a considerably more active role in accelerating wound healing and preventing the complications and costs inherent in chronic wounds.

The market for even commodity-like dressings products continues to grow, driven by increased prevalence of many wound types and supported by these products’ ease of use and low cost.  However, the markets for more advanced products are growing at substantially higher rates as a result of the ability of these products (or the perception) to provide faster, less costly or otherwise better wound healing.  The net effect is that all segments of wound management product sales are growing (see Exhibit 1), although a variable rates, resulting in considerable shifts in each segment’s share of the total wound market (see Exhibit 2).

Exhibit 1


Source: MedMarket Diligence, LLC; Report #S249.

Exhibit 2


Source: MedMarket Diligence, LLC; Report #S249.

Consequently, the rapid growth in sales of advanced products is shifting the balance of sales away from traditional products.

As rapid as the growth of advanced wound product sales is, there is still a long competitive battle to wrest control of a large share of wound management from traditional bandages and dressings (see Exhibit 3).

Exhibit 3

3013 03 27 wound pie

Source: MedMarket Diligence, LLC; Report #S249.

Future Wound Management: More Equipment, Biotech; Less Lowtech

The history of wound management has been dominated by a simple premise of getting wounds closed, keeping them covered and letting the body heal itself.  But the demand to accelerate the wound healing process, especially for a growing caseload of chronic wounds (driven by increased diabetes prevalence, aging population, and others) is driving a shift way from a passive role in wound management to one where materials are used to draw away exudate, kill bacteria, and maintain healing-optimized moisture levels; equipment is used to also remove exudate and otherwise stimulate the healing process; natural and bioengineered grafts are used to intervene for extreme wound types; growth factors and other biologicals are used to supplement the natural cascade of wound healing.  In short, wound healing is moved from being eminently passive to decidedly active, with considerably more medtech and biotech, with less “low-tech” (e.g., simple bandages and dressings).

The resulting balance of the overall wound care market distributed across multiple product and technology types will represent markedly different pictures between now and the next decade.

Below is illustrated the shift in wound care technologies, from a percentage of total basis and absolute share of product revenues basis:


Source: MedMarket Diligence Report #S249, “Wound Management, Worldwide Market and Forecast to 2021: Established and Emerging Products, Technologies and Markets in the Americas, Europe, Asia/Pacific and Rest of World.”  Published March 2013.


Source: MedMarket Diligence Report #S249



Growth factors in wound management

MedMarket Diligence has expanded its global wound care market analysis to address the current market and forecast outlook for growth factors developed and applied to accelerating wound care.

Extensive research has demonstrated that wound fluid is rich in growth factors. Growth factors are naturally occurring proteins found primarily in platelets and macrophages. They are needed for normal wound healing to promote growth and migration of fibroblasts, endothelial cells and keratinocytes.

For this reason, growth factors have been heavily studied and already have demonstrated their potential to advance wound care.

Report #S249, “Wound Management, Worldwide Market and Forecast to 2021: Established and Emerging Products, Technologies and Markets in the Americas, Europe, Asia/Pacific and Rest of World,” provides detailed global, regional and country-specific data on growth factors in wound care.