Reference reports in Ophthalmology, Coronary Stents and Tissue Engineering

MedMarket Diligence has added three previously published, comprehensive analyses of  medtech markets to its Reference Reports listings. The markets covered in the three reports are:

  • Ophthalmology Diagnostics, Devices and Drugs (see link)
  • Coronary Stents: Drug-Eluting, Bare, Bioresorbable and Others (see link)
  • Tissue Engineering, Cell Therapy and Transplantation (see link)

Termed “Reference Reports”, these detailed studies were initially completed typically within the past five years. They now serve as exceptional references to those markets, since fundamental data about each of these markets has remained largely unchanged. Such data includes:

  • Disease prevalence, incidence and trends (including credible forecasts to the present)
  • Clinical practices and trends in the management of the disease(s)
  • Industry structure including competitors (most still active today)
  • Detailed appendices on procedure data, company directories, etc.

Arguably, a least one quarter of every NEW medtech report contains background data encompassing the data listed above.  Therefore, the MedMarket Diligence reports have been priced in the single user editions at $950 each, which is roughly one quarter the price of a full report.

See links above for detailed report descriptions, tables of contents, lists of exhibits and ordering. If you have further questions, feel free to contact Patrick Driscoll at (949) 859-3401 or (toll free US) 1-866-820-1357.

See the comprehensive list of MedMarket Diligence reports at link.


Developed versus emerging markets in advanced wound management

Continuing a vein of discussion posted previously, Trickle Down Technologies in Medtech, it is worth looking at the advanced wound management products represented by hemostats (i.e., hemostatic agents, like ZMedica's QuikClot), fibrin and other sealants, high-strength medical adhesives and products for prevention of post-surgical adhesion and look at their relative size in a set of  well-developed economies like that of the Americas versus the same for emerging markets, such as represented by Asia/Pacific excluding Japan and Korea.

The point of this comparison is to illustrate that markets for advanced technologies grow first and fastest in advanced economies.  In the case of advanced wound management products, least "advanced" product is hemostats, while the most advanced is high-strength medical adhesives (even moreso than anti-adhesion products).  See below in graphics comparing in absolute terms the market segmentation (stacked column chart) and the relative size of segments (two pie charts) for the Americas and Emerging Asia/Pacific.


Source: MedMarket Diligence Report #S190.

Hemostats represent a relatively low hurdle to market entry, since the important functions of the product are simply to stop bleeding without being toxic.  On the other end of the spectrum is high-strength medical adhesives, which must create strong tissue adhesion without toxicity and, as has been demonstrated by toxic cyanoacrylates, this is indeed a challenge.

Having said this, despite the technical challenge, which exists independently of geographic market differences, the real challenge (beyond gaining U.S. or EU regulatory approval) is bringing the price of these advanced products down to levels can accelerate their more rapid introduction into growth markets like the emerging Asia/Pacific (see CHINA).

Spine surgery largely unfazed by recent market challenges

Few medical device markets have demonstrated the kind of staying power — prices, procedure growth, market growth — shown by spine surgical technologies.  The swelling caseload of new patients, the persistent clinical need and the stream of innovations from manufacturers in this arena have enabled growth rates that have not recently been seen in most other device markets.

Of course, the market has been pinched by insurer pushback on some procedures (e.g., fusion when degenerative disc disease is involved), price pressures on some established devices and, in the U.S., regulatory reform that is long in coming.

A definite kind of demand inelasticity exists in spine disorders and trauma that has enabled it to be an area in which manufacturers have been able to succeed despite the capital restrictions and recessionary forces that have plagued markets since at least 2008.

Spine surgery technologies are comprised of the following discrete segments:

  • Posterior Pedicle Screw Fusion Systems
  • Anterior Cervical Plate Systems
  • Anterior Thoracolumbar Plate Systems
  • Anterior Lumbar Interbody Fusion (ALIF) devices
  • Transforaminal Lumbar Interbody Fusion (TLIF) devices
  • Posterior Lumbar Interbody Fusion (PLIF) devices
  • Axial Lumbar Interbody Fusion (AxiaLIF) devices
  • Interspinous Process Spacer (ISP)
  • Cervical Artificial Discs
  • Lumbar Artificial Discs
  • Vertebroplasty
  • Balloon Kyphoplasty
  • Allografts
  • Demineralized Bone Matrix (DBM)
  • Bone Morphogenetic Proteins (BMPs)

Below is an exhibit (drawn from the 2011 MedMarket Diligence worldwide report on spine surgery) illustrating the different growth in spine surgery technology segments.

Source: MedMarket Diligence Report #M520.

Posterior pedicle screw fusion systems currently represent the largest share of the global spine technology market, a dominance that will persist through the forecast period based on its large established base. However, as is evident in the uptake of new spine technologies, there is ample opportunity for participants in all but a few sectors that are declining in absolute or relative terms.

Advanced wound closure: still a growth market

The market for advanced wound closure and securement technologies continues to evolve at a steady pace.  This $10 billion+ market is comprised of sutures, staples, other mechanical wound closure, tapes, hemostats, fibrin and other sealants, high strength medical adhesives, and post-surgical adhesion prevention products.

Source: MedMarket Diligence, LLC; Report #S180.

Despite the fact that this seemingly represents a lot of products operating in the same "space", there are in fact a large number of active companies (we conservatively profiled 104 different companies).  This reflects the fact that this market still has many active growing segments (envision the size of the "sutures, staples" segment in the pie above as representing, literally, a large slice of pie of interest to companies who have yet only taken a few bites out of the other slices).  Traditional wound closure and securement, including sutures, staples and the more recent mechanical closure, still represents a very large (almost $8 billion) market that is being targeted by a growing portfolio of advanced products that have demonstrated much potential to replace, or at least augment, these established wound closure technologies.

During the 1980s, the United States, by virtue of its demonstrated aversion to the risk represented by the many blood-derived advanced wound closure technologies (e.g., fibrin and other sealants and hemostats), fell behind other country markets that were more amenable to these advanced products. But blood-screening methods, purification and other methods addressed this risk to the satisfaction of the markets, such that the current market for these products now represents the more typical global market in which the largest single national market for advanced wound closure and securement products is the U.S.


Source: MedMarket Diligence, LLC; Report #S180.

Spinal disease and trauma map

Diseases and disorders of the spine are numerous and complex.  The spine itself is a complex anatomy with structure and function that are susceptible to a wide range of conditions, whether by trauma or disease, that have been the focus of continued development of medical technology with the purpose of restoring (or approximating) as much of that structure and function as possible.

For the sake of illustration, below is a map of the diseases and disorders (including trauma) of the spine:

Source: Pending MedMarket Diligence Report #M520, "Worldwide Spine Surgery 2011: Products, Technologies, Markets & Opportunities, Worldwide, 2010-2020." (Publishing May/June 2011)

Surgical Sealants, Glues, Hemostasis, and Other Wound Closure Well Established Yet Still Growing Strong, According to New MedMarket Diligence Report

With its products filling many niches, established companies making acquisitions, startups still entering the market and clinical practice steadily adopting products in existing and new uses, the sealants, glues and related products markets reflect the characteristics of both well established and emerging technologies. A new report from MedMarket Diligence details the status and outlook for the products, technologies, companies and global markets.

Foothill Ranch, CA (PRWEB) October 28, 2010 — According to the newly released report, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015″, from MedMarket Diligence, the market for surgical closure and securement has entered a phase in which major driving forces are the introduction of new procedures and techniques by the surgical profession, the development by the medical device industry of new wound closure devices and biomaterials, and the growing willingness of surgical specialists to use these devices in appropriate circumstances. There is now a continuum between simple closure using sutures and the use of specially designed devices and delivery systems with new bioresorbable securement materials either as supplements to conventional closure methodology or as stand-alone replacements.

“There is a broad spectrum of activity in the ‘advanced wound closure’ or ‘securement’ market, with the characteristics of disruptive innovation of new technologies all the way through market consolidation and price erosion,” says Patrick Driscoll of MedMarket DIligence. “Surgical sealants, glues and related products are to some degree routine in clinical practice and to some degree still seeking to prove their utility in new applications, while traditional sutures, staples, clips, tapes and other products are struggling to maintain their competitiveness.”

Globally, the market has reached $10 billion for surgical sealants, glues, hemostasis, sutures, staples/clips, tapes and anti-adhesion products, with annual sales growth among the constituent segments ranging from 2.6% to in excess of 14% annually. The market continues to be characterized by the introduction of many new products, formation of new companies, growth of existing applications, and adoption of new applications. Simultaneously the market is evolving through consolidation and other dynamics typical of established markets.

The MedMarket Diligence report #S180, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015″, details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments in this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a market and technology assessment and forecast of surgical sealants, glues, hemostasis, other wound closure and anti-adhesion. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent surgical adhesions. The report provides a worldwide historic (from 2008), current and annual forecast to 2015 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade. The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan, Korea and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a five-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

The MedMarket Diligence report, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015,” is described in detail, with a complete table of contents and list of exhibits at

The report may be purchased for immediate download from or may be purchased via order form at

MedMarket Diligence provides data and insight to the medical products, investment and other industries on advanced medical technologies through focused medical technology market and assessment Reports and the Medtech Startups Database.

Surgical securement market, Latin America

The securement market, encompassing fibrin sealants/glues, high strength glues (cyanoacrylates, others), hemostatic agents, sutures, staples, other mechanical closure and products for the prevention of post-surgical adhesion, in most segments reflects an advanced wound technologies market.  As is the cast with virtually all medtech markets, the dominant geographies driving securement revenues are the U.S., Europe and Asian countries like Japan and Korea.  However, considerable attention is being given to Latin America, based on the level of healthcare market development, the population and potential caseload, and the relative ease of distribution, particularly for U.S.-based manufacturers (although, not to overstate the opportunity, since by comparison to the well established western markets, Latin America is clearly less driven by high healthcare expenditure and utilization of advanced technologies).

By capitalizing on existing distribution networks, trade agreements and the simple proximity of geography for major U.S. manufacturers, the opportunity of Latin America has been a profitable consideration.

Source: MedMarket Diligence, LLC; report #S180.