Clinical Management of Obesity Worldwide

Publishing in November 2010:

Products, Technologies and Markets Worldwide for the Clinical Management of Obesity, 2009-2019

– 300 pages  – 95 Exhibits  – 54 Company Profiles  – February 2011  – Report #S835

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[This report description and table of contents is also available at report S835.]

This report is a detailed market and technology assessment and forecast of the products and technologies in the clinical management of obesity (bariatrics). The report describes the current and projected patient population in obesity, detailing their incidence worldwide, with available incidence by country for the U.S., major European countries, major countries in Asia/Pacific (including Japan, China, India and Australia), the clinical practices in their management to encompass surgical approaches, medical supervised severely restricted diets, drug therapies, OTC treatments, biopharmaceuticals, non-pharmacologic approaches and weight maintenance approaches. The report describes clinical trends in the management of the obese. The report details the products on the market and the status of those in development for bariatric surgery, drug therapy, gastric stimulation devices, brain stimulation devices, combination therapies and genetic therapy and other therapies under development, and will provide current and worldwide market forecasts (2009-2019) separately for pharmaceuticals (with separate segment forecast data for satiety, malabsorption, appetite suppression and combination drugs) and devices (with separate segment forecast data for stomach restriction artificial fullness, malabsorption, gastric emptying and appetite suppression), with current (2009) market shares of the leading competitors in each segment. The report profiles 60 of the leading competitors, detailing current and potential position in the market, their products and their market strengths and likelihood of future success.

Preliminary Table of Contents

EXECUTIVE SUMMARY

SECTION 1: CLINICAL BACKGROUND OF OBESITY
1.1 Clinical Diagnosis of Obesity
1.1.1 Body Mass Index Scale
1.1.2 Measuring BMI vs. Measuring Adiposity
1.1.3 Classification of Obesity
1.1.4 Overweight, Obesity, Morbid Obesity, Super Obesity
1.1.5 Genetic Testing for Obesity
1.2 Obesogenic Influences
1.2.1 Dietary Changes Over the Last Twenty Years
1.2.2 Sedentary Lifestyles
1.2.3 Ongoing Research into Causes
1.3 Metabolic Pathways of Energy Homeostasis
1.3.1 Role of the Hypothalamus
1.3.2 Role of the Stomach
1.3.3 Role of the Small Intestine
1.3.4 Role of the Pancreas
1.3.5 Role of Adipose Tissue, An Endocrine Organ
1.3.6 Other Peptides
1.3.7 Obesity as Survival Mechanism
1.4 Co-Morbidities of Overweight and Obesity
1.4.1 Metabolic Syndrome
1.4.2 Effects of Obesity on Immune Function
1.4.3 Racial Differences in Co-morbidities
1.4.4 Type 2 Diabetes and Insulin Resistance
1.4.5 Hypertension
1.4.6 Dyslipidemia
1.4.7 Depression
1.4.8 Osteoarthritis
1.4.9 Asthma
1.4.10 Sleep apnea
1.4.11 Obesity and Cancer
1.5 Global Incidence and Prevalence of Obesity
1.5.1 By Geographic Region
1.5.1.1 USA, Canada, Mexico, Brazil
1.5.1.2 European Union
1.5.1.3 Asia-Pacific
1.5.2 By Age Group
1.5.2.1 Incidence and Prevalence among Children
1.5.2.2 Incidence and Prevalence among Elderly
1.5.3 Incidence and Prevalence of Morbid Obesity
SECTION 2: THE IMPACT OF OBESITY
2.1 Costs Related to Treating Obesity and Co-Morbidities
2.1.1 Current Healthcare Expenses
2.1.2 Breaking the Bank: Predictions of Future Healthcare Expenses
2.1.3 Healthcare Reform and Obesity
2.2 Impact on Businesses
2.2.1 Increased Health Insurance Costs
2.2.2 Increase in Workers’ Compensation Costs
2.2.3 Debate: Pay Employees to Lose Weight?
2.3 Legislating Prevention and Weight Loss
2.3.1 Changing Society: Educating Children as well as Adults
2.3.2 Pressure on the Food Industry
SECTION 3: CLINICAL APPROACHES TO THE TREATMENT OF OVERWEIGHT AND OBESITY
3.1 Role of Behavior Modification and Lifestyle Changes
3.1.1 Behavior Modification Programs: Decidedly Mixed Success
3.1.2 Medically Supervised Low Calorie and Very Low Calorie Diets (LCDs and VLCDs)
3.1.3 Why Diets Usually Fail
3.2 Pharmaceutical Treatment of Obesity: Past, Present and Future Drugs
3.2.1 The Bloom is Off the Rose: Promising Drugs Which Have Failed, and Why
3.2.2 Drugs Currently on the Market
3.2.2.1 Appetite Suppression Drugs
3.2.2.2 Malabsorption Drugs
3.2.2.3 Satiety Drugs
3.2.2.4 Combination Drugs
3.2.3 Areas of Pharmaceutical Research
3.2.3.1 Melanocortin Receptor System
3.2.4 Drugs in the Pipeline—But Will They Hold Up?
3.2.4.1 Appetite Suppression Drugs
3.2.4.2 Malabsorption Drugs
3.2.4.3 Satiety Drugs
3.2.4.4 Combination Drugs
3.2.5 Safety: The Major Diet Drug Hurdle
3.2.6 After ‘Phen-Fen’ Experience, Will Physicians Prescribe Off-Label Combinations?
3.3 Non- Pharmaceutical Options for Treating Obesity
3.3.1 Permanent Surgical Modification
3.3.2 Surgical Revision of Bariatric Procedures
3.3.3 Short-Term Surgical/Device Solutions
3.3.4 Invasive Devices to Treat Obesity
3.3.4.1 Devices to Restrict Stomach Volume
3.3.4.2 Artificial Fullness Devices
3.3.4.3 Malabsorption Devices
3.3.4.4 Devices to Control Gastric Emptying
3.3.4.5 Appetite Suppressive Devices
SECTION 4: MARKET ASSESSMENT
4.1 Global Market for the Treatment of Obesity
4.1.1 Pharmaceuticals
4.1.1.1 Satiety
4.1.1.2 Malabsorption
4.1.1.3 Appetite Suppression
4.1.1.4 Combination Drugs
4.1.2 Devices
4.1.2.1 Stomach Restriction
4.1.2.2 Artificial Fullness
4.1.2.3 Malabsorption
4.1.2.4 Gastric Emptying
4.1.2.5 Appetite Suppression
4.2 Market Shares of Leading Companies
4.2.1 Leading Pharmaceutical Companies
4.2.2 Leading Device Companies
4.3 Americas Market for the Treatment of Obesity
4.3.1 USA
4.3.2 Canada
4.3.3 Mexico
4.3.4 Brazil
4.4 European Market for the Treatment of Obesity
4.4.1 United Kingdom
4.4.2 France
4.4.3 Germany
4.4.4 Italy
4.4.5 Spain
4.4.6 Rest of Europe
4.5 Asia-Pacific Markets for the Treatment of Obesity
4.5.1 Japan
4.5.2 India
4.5.3 China
4.5.4 Australia
4.5.5 Russia
4.6 ROW Markets for the Treatment of Obesity
4.7 Market Drivers and Restraints
4.7.1 Drivers
4.7.2 Restraints
4.8 Marketing Opportunities
SECTION 5: COMPANY PROFILES
5.1 Abbott Laboratories
5.2 Allergan
5.3 Amylin Pharmaceuticals
5.4 Arena Pharmaceuticals
5.5 AstraZeneca
5.6 BAROnova Therapeutics
5.7 BaroSense
5.8 Covidien
5.9 CR Bard, Inc.
5.10 Eli Lilly & Company
5.11 EndoGastric Solutions
5.12 EndoSphere
5.13 EndoVx
5.14 EnteroMedics
5.15 Ethicon Endo-Surgery (JNJ)
5.16 Gelesis, Inc.
5.17 GI Dynamics
5.18 GlaxoSmithKline
5.19 Helioscopie
5.20 Interleukin Genetics
5.21 IntraPace
5.22 Merck
5.23 Nestlé Healthcare Nutrition
5.24 NeuroSearch A/S
5.25 Novo Nordisk
5.26 Orexigen
5.27 Pfizer
5.28 ReShape Medical
5.29 Rhythm Pharmaceuticals
5.30 SafeStitch Medical, Inc.
5.31 Sanofi Aventis
5.32 Satiety
5.33 Scientific Intake, LLC
5.34 Silhouette Medical, Inc.
5.35 Spatz FGIA, Inc.
5.36 USGI Medical
5.37 ValenTx, Inc.
5.38 Verva Pharmaceuticals Ltd.
5.39 Vivus, Inc.
APPENDIX I: CLINICAL TRIALS
APPENDIX II: APPENDIX
Company Contact Details
Terms and Abbreviations Used in this Report

Surgical Sealants, Glues, Hemostasis, and Other Wound Closure Well Established Yet Still Growing Strong, According to New MedMarket Diligence Report

With its products filling many niches, established companies making acquisitions, startups still entering the market and clinical practice steadily adopting products in existing and new uses, the sealants, glues and related products markets reflect the characteristics of both well established and emerging technologies. A new report from MedMarket Diligence details the status and outlook for the products, technologies, companies and global markets.

Foothill Ranch, CA (PRWEB) October 28, 2010 — According to the newly released report, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015”, from MedMarket Diligence, the market for surgical closure and securement has entered a phase in which major driving forces are the introduction of new procedures and techniques by the surgical profession, the development by the medical device industry of new wound closure devices and biomaterials, and the growing willingness of surgical specialists to use these devices in appropriate circumstances. There is now a continuum between simple closure using sutures and the use of specially designed devices and delivery systems with new bioresorbable securement materials either as supplements to conventional closure methodology or as stand-alone replacements.

“There is a broad spectrum of activity in the ‘advanced wound closure’ or ‘securement’ market, with the characteristics of disruptive innovation of new technologies all the way through market consolidation and price erosion,” says Patrick Driscoll of MedMarket DIligence. “Surgical sealants, glues and related products are to some degree routine in clinical practice and to some degree still seeking to prove their utility in new applications, while traditional sutures, staples, clips, tapes and other products are struggling to maintain their competitiveness.”

Globally, the market has reached $10 billion for surgical sealants, glues, hemostasis, sutures, staples/clips, tapes and anti-adhesion products, with annual sales growth among the constituent segments ranging from 2.6% to in excess of 14% annually. The market continues to be characterized by the introduction of many new products, formation of new companies, growth of existing applications, and adoption of new applications. Simultaneously the market is evolving through consolidation and other dynamics typical of established markets.

The MedMarket Diligence report #S180, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015”, details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments in this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a market and technology assessment and forecast of surgical sealants, glues, hemostasis, other wound closure and anti-adhesion. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent surgical adhesions. The report provides a worldwide historic (from 2008), current and annual forecast to 2015 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade. The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan, Korea and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a five-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

The MedMarket Diligence report, “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015,” is described in detail, with a complete table of contents and list of exhibits at http://mediligence.com/rpt/rpt-s180.htm.

The report may be purchased for immediate download from http://mediligence.com/store/page41.html or may be purchased via order form at http://mediligence.com/order_forms/s180_order.pdf.

MedMarket Diligence provides data and insight to the medical products, investment and other industries on advanced medical technologies through focused medical technology market and assessment Reports and the Medtech Startups Database.

Report: Surgical Sealants, Glues, Wound Closure and Anti-adhesion Worldwide

MedMarket Diligence (MMD) has published its 2010 report on the worldwide market for surgical sealants and related products in surgical and traumatic wound management.

The analysis by MMD reveals the size of the evolving opportunity for a diverse set of products in global markets. Based on extensive primary and secondary research, and leveraging MMD’s position as the leading source for the medtech industry on the subject, the report provides industry participants and hopefuls with invaluable data and insights.

The report is described below and at link

This report details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, from tapes, sutures and staples to hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments in this huge and rapidly growing worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.

This report is a market and technology assessment and forecast of surgical sealants, glues, hemostasis, other wound closure and anti-adhesion. The report details the current and emerging products, technologies and markets involved in wound closure and sealing using sutures and staples, tapes, hemostats, fibrin and sealant products, medical adhesives and products to prevent surgical adhesions. The report provides a worldwide historic (from 2008), current and annual forecast to 2015 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the coming decade.  The report provides specific forecasts and shares of the worldwide market by segment for the U.S., Europe (United Kingdom, German, France, Italy, BeNeLux), Latin America, Japan, Korea and Rest of World.

The report provides background data on the surgical, disease and traumatic wound patient populations targeted by current technologies and those under development, and the current clinical practices in the management of these patients, including the dynamics among the various clinical specialties or subspecialties vying for patient population and facilitating or limiting the growth of technologies.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a five-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

See link for complete table of contents and list of exhibits.  The report may be ordered for immediate download from link.

Disparities between U.S., Japanese surgical sealants, glues markets

Historically, there have been some distinct differences between the markets for surgical sealants, glues and wound closure in the United States and Japan.  In part, this arises from Japan’s earlier adoption of emerging wound closure technologies than the U.S., particularly surgical sealants, which had delayed U.S. introduction due to concerns about blood-borne virus transmission.  While those differences have largely been dissipated by several years of active fibrin sealant marketing in the U.S., there remain other difference due to differences in clinical practice, product adoption, economics and other forces.

Below is illustrated the relative distribution of the surgical sealants, glues and wound closure markets (excluding sutures/staples) in the U.S. and Japan.

Source: MedMarket Diligence, LLC; (pending) report #s180, “Surgical Sealants, Glues, Wound Closure and Anti-Adhesion 2010-2015.”

There are a number of potential reasons (we are exploring) behind the differences, including the relatively higher hemostat usage in the USA and the relatively higher hi-strength adhesive and post-surgical adhesion product usage in Japan.  In part, both of these differences reflect an advanced market in Japan where, arguably, two of the most emerging areas of the “securement” market include high strength glues and post-surgical adhesion products, the two areas where the relative difference is greatest.  In terms of hemostats, these represent a broad range of product types (collagens, gels, others) that have been more well established in the U.S., but which show less product and technical development than high strength glues and post-surgical adhesion products.

The growing need for diabetes management globally

Population growth, trends in obesity prevalence, economic drivers and other forces are creating an enormous need for products in the management of diabetes.  In the aggregate, over the next twenty years, the prevalence of diabetes in the adult population (age 20-79) will increase from 285 million worldwide in 2010 to 438 million in 2030, an overall increase of 54%.

NAC: North America and Caribbean region; MENA: Middle East and North Africa region; SEA: South East Asia region; EUR: European region; SACA: South and Central America region; WP: Western Pacific region; AFR: Africa region.

Source: IDF Diabetes Atlas and MedMarket Diligence, LLC.

 

The greatest number of newly diagnosed diabetes mellitus patients are arising in South East Asia (SEA), Western Pacific (WP) and Middle East and North Africa (MENA), as illustrated below (figures in millions):

Source: IDF Diabetes Atlas and MedMarket Diligence, LLC.

 

Growth of the diabetes patient population in North America and Europe, with its well developed economies and healthcare system infrastructure, is occurring at a compound annual growth rate, from 2010 to 2030, of 1.8% in North America and 0.9% in Europe. These new patients will be readily integrated into the existing infrastructure of clinical management.  By contrast, however, the large numbers of patients arising from South East Asia, the Western Pacific and the Middle East and North Africa will demand development of infrastructure to manage these patients and supply the appropriate diagnostic and therapeutic products for management of their diabetes mellitus.


Data is drawn from the International Diabetes Federation and MedMarket Diligence Report #D510, "Worldwide Diabetes Management."

Sealants, glues, wound closure, anti-adhesion market segments by country

The global market for surgical sealants, glues, other wound closure and anti-adhesion products (collectively referred to as "securement "products) is, like many medtech markets, dominated by the U.S., followed by Europe.  But as one examines the performance of individual product segments in this market, it becomes clear that local markets have enough differences in their drivers to result in surprising variation from one another.

Below are illustrated the absolute size of the markets for products in securement by country and the relative contribution of revenues from each securement product type by country.  The differences stand out.

Source: Preliminary findings, Report #S180, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2010-2015". (Publishing October 2010)

Ablation Technologies Competing for Growing Patient Volume and Penetration of Clinical Practice, According to New MedMarket Diligence Report

Ablation technologies are a growth medtech field driven as much by physicians pursuing larger caseload as manufacturers developing innovative technologies, according to a new global report from MedMarket Diligence.

(PressMethod) – Surgical procedures focus on a wide range of clinical endpoints — the creation of a lesion to block aberrant cardiac rhythms, the destruction of cancerous tissue, the ligation of tissues with associated hemostasis, and many others — which has driven the development of an array of ablation technology types that are now competing aggressively with each other for a growing caseload of procedures. The ablation technologies with some of the most rapidly growing use rates are cryotherapy and radiofrequency ablation, followed by ultrasound, laser and, due to innovations in its implementation, radiotherapy. These are among the findings in a new medical technology report from MedMarket Diligence.

Although the applications of ablation devices include a number of aesthetic treatments, the majority of applications remain chronic disorders in areas which include cancer, cardiovascular, urology, gynecology and orthopedics. Many of these disorders are age-related, and the related device segments are driven by the aging of the global populations. Other market drivers include the Chinese government's push to modernize its healthcare facilities by building 400 hospitals per year, and developed country populations which are demanding anti-aging treatments, to which physicians are responding by purchasing equipment.

"Like the most successful medical technologies, ablation technologies have as their underlying driver for success the ability of physicians to capture greater caseload due to their ability to promote the clinical efficacy of ablation, faster healing times, fewer complications and many other benefits," says Patrick Driscoll, President of MedMarket Diligence. According to Driscoll, the top ablation technologies are growing at nearly 20% annually in manufacturer revenues. These include control systems, instrumentation and probes and other disposables used during the procedures.

The MedMarket Diligence report, "Ablation Technologies Worldwide Market, 2009-2019: Products, Technologies, Markets, Companies and Opportunities", describes alternative energy-based technologies and the nature of their effect on soft tissue, the underlying basis of the technology, the requisite systems for their use (including capital equipment, devices and disposables), and their strengths and weaknesses for specific clinical applications. The report details current and anticipated target applications and assesses the current and forecast caseload for each energy-based therapeutic considering competition from any and all alternative energy-based or other therapeutics, with current and worldwide market forecasts (2009-2019) segmented by technology type and specific clinical segment. The report provides segmentation of the worldwide ablation market by both ablation technology and region/country: Americas (USA, Canada, Mexico, Brazil), Europe (Germany, United Kingdom, France, Italy, Spain, BeNeLux), Asia/Pacific (Japan, China, India, Australia) and Rest of World. The report details the current and emerging products, technologies and markets for each energy-based therapy. The report profiles 76 key companies in this industry detailing their current products, current market position and products under development.

The report is described in detail, including table of contents and list of exhibits, at link. The report may purchased for immediate download at link.

 

New Technologies in Type 1 and Type 2 Diabetes Management

(See PRLog press release at link.)

As well established as the practices are for the management of types 1 and 2 diabetes, a raft of new technologies, from modest to radical, are steadily entering clinical practice and the industry, according to a new report from MedMarket Diligence.

FOR IMMEDIATE RELEASE

PRLog (Press Release) – Aug 16, 2010 – The diagnosis, monitoring and management of both insulin-dependent diabetes mellitus (also known as Type 1) and non-insulin dependent diabetes mellitus (aka Type 2) is a well established practice of regulating blood glucose levels. Nonetheless, manufacturers have steadily developed new technologies that continue to improve the management of the disease by reducing burden on patients, reducing the incidence of diabetes-related complications and reducing the overall cost of the disease on healthcare systems.

“Without a doubt, the 10-year study known as Diabetes Control and Complications Trial, or DCCT, played an enormous role in validating the technologies that now routinely serve to improve the quality of life for diabetics,” says Patrick Driscoll, President of the medical technology business research firm MedMarket Diligence. “But the steady growth in diabetes prevalence worldwide, driven by increased prevalence of obesity, demographic trends and other forces, combined with persistent demand for ever less intrusive monitoring technologies and better long-term blood glucose management, creates an enormous opportunity for new technology development by diabetes product manufacturers.”

According to Driscoll, and detailed in the MedMarket Diligence report (see link), products in diabetes management represent an enormous $36 billion global market annually, encompassing insulin, blood glucose meters, lancets, test strips, insulin pumps, syringes (and other delivery devices), continuous blood glucose meters and a broad range of anti-diabetic drugs (oral hypoglycemic agents). Each of these product areas has many competitors offering and developing new products (even the area of insulin has a dozen competing companies), with a steady stream of innovations being introduced to the market and clinical practice. Moreover, aggressive research has continued to push for more advanced solutions to diabetes, including novel insulin delivery methods, pancreas transplants, islet cell transplants, stem cell approaches, antibody treatment, vaccines, novel drugs, new continuous blood glucose monitoring systems and the “holy grail” of diabetes management, a closed-loop blood glucose monitoring and insulin pump system (sometimes referred to as an “artificial pancreas”), which may be approved for marketing in the very near future.

Growth in the market for diabetes management products ranges globally from a low of about 11% annually in Europe to nearly 24% annually in Asia. Overall, the U.S. and Europe, with their advanced healthcare markets and payment systems, still represent an aggregate 68% of the global market. By product area, the segments driving the largest annual revenues are insulins and anti-diabetic drugs, comprising almost two thirds of the global sales of diabetes management products.

The MedMarket Diligence report #D510, “Products, Technologies, Markets and Opportunities in Diabetes Management Worldwide, 2009-2018,” details the worldwide incidence and prevalence by country/region of Type 1 and Type 2 diabetes and details the current and projected market for diagnostic and therapeutic products in the management of diabetes, including anti-diabetic drugs, alternative insulin types, blood glucose monitoring (including continuous monitoring devices), insulin pumps, and other established and emerging products in diabetes management. The report provides an emphasis of detail on the status of development of novel products including noninvasive monitoring, oral/inhaled/other insulin delivery. The report details the clinical and technology developments underlying this huge and evolving worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity. Separate size, growth and competitor share data are presented for the U.S., European, Asia/Pacific and Rest of World. The report profiles active companies including detailed profile information on major competitors, brief profiles of companies with less sizeable current or potential positions in the market, plus additional profiles of companies with novel or advanced research activities in the market.

The report establishes the current worldwide market size for major technology segments as a baseline for and projecting growth in the market over a ten-year forecast. The report also assesses and projects the composition of the market as technologies gain or lose relative market performance over this period.

The report is described, with complete table of contents and list of exhibits at http://mediligence.com/rpt/rpt-d510.htm and may be accessed for immediate download via http://mediligence.com/store/page34.html.

Segmentation of global ablation market by geography and modality

The global market for ablation technologies is characterized, like many medtech markets, by a dominance of revenues in western economies.  There are nonetheless distinct patterns in the share of ablation by modality from one geography to the next.

Below is a simple representation of the global ablation market by major region and modality (aggregated from the detail by country in MMD report #S520):

Source: MedMarket Diligence, LLC; Report #S520, "Ablation Technologies Worldwide Market."