Products in Post-Surgical Adhesion

Post-operative adhesions tend to arise as a result of exposure of internal connective tissues to air and instrumentation during the surgical procedure, and any irritation associated with the procedure to internal organs. Abdominal surgery often leads to some form of adhesion formation, as do cardiology procedures. There are roughly 8 million–9 million abdominal surgeries, more than 2 million gynecology surgeries, and 9 million cardiovascular surgeries every year, with about 1.7 million procedures associated with some risk of critical adhesion formation. Thus there is enough risk for adhesions from these procedures to encourage the use of adhesion prevention products in approximately 10% of the cases over the next decade.

Products that reduce the risk of adhesions forming following surgery are made from a variety of materials.  These different formulations are all designed to minimize the irritation while eventually resorbing on site.

Below is illustrated the range of different material types that comprise the anti-adhesion products on the market and in development.  These include the leading products by Ethicon/Johnson & Johnson  (Interceed), Covidien (DuraSeal and others) and Genzyme (Seprafilm).

From “Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2008-2015”, Report #S180.

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