Medical and Surgical Sealant Market Consolidation

UPDATE: See October 2014 Report #S192, “Worldwide Market for Surgical Sealants, Glues, and Wound Closure, 2013-2018, 2013-2018.”

The field of tissue glue and sealants has been prolific for its formation of new companies pursuing the development and marketing of these products for medical and surgical applications. (The MedMarket Diligence report #S192 profiles 104 companies active in this market.)

As the market for these products has moved past its infancy and more companies have gained regulatory approval and begun marketing products, a natural consequence has been the consolidation of the industry as a number of key players expand their portfolio or otherwise deepen their market presence via acquisition.

Below is a select group of acquisitions in this space over the past decade:

MoistureThe lack of sufficient moisture, or conversely an excess of moisture, can slow down repair. Lack of moisture often occurs with dry wound healing approaches; this stops cellularity, dries out cells and prevents the flow of humoral factors essential for removal of for pathogens and cell communication. It ultimately prevents the movement of keratinocytes for epithelialization. Too much moisture can lead to maceration, which causes osmotic damage to cells and slow healing, as well as breakdown of surrounding tissues.
InfectionInfection by micro-organisms can significantly slow down healing, leading to an extended inflammatory phase and cell necrosis. Some organisms in the wound are not detrimental, and evidence suggests that some microbes accelerate healing. However, organisms like Staphylococcus aureus and many anaerobic microbes are pathogenic and will live off the tissues.
DebrisThe presence of debris within the wound will delay healing. It is essential to remove any contaminating material that may be a source of infection, or which may delay healing through chemical or physical obstruction.
TemperatureTissue healing tends to be optimal at higher than normal physiological temperature. The exact reasons are not clear, but at higher temperatures enzymes and cell metabolism tend to achieve faster removal of pathogens and greater catabolic activity.
PressurePressure is a major extrinsic factor that can be detrimental to healing. This is why significant effort has gone into development of pressure relief products for use in situations involving mechanical stress. In addition, a number of devices have been evolved which are designed to modify the pressure around a wound to facilitate healing.

Source: MedMarket Diligence, LLC; Report #S175, “Worldwide Surgical Sealants, Glues and Wound Closure Market, 2009.” (See updated report #S192.)

The trend toward consolidation has gained greater momentum as a result of the global financial market meltdown of 2008-2009, with the limitation on credit and invesment having a particularly hard impact on early stage and startup companies.

See updated report #S192.

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