Cyanoacrylate products are the main form of high-strength surgical glue that is approved for human clinical use in the worldwide market. A number of new materials are under development for internal use in particular, but these represent new chemical entities and their commercialization is likely to be delayed by regulatory requirements.
Sutures will be replaced by cyanoacrylate glues in many procedures over the next 10 years but these adhesives do not represent the ideal alternative to suturing. Cyanoacrylate glues used for external skin closure are approximately five times less strong than sutures, and cyanoacrylates produce cytotoxic compounds as part of the curing process when used for securing torn or excised tissue. This has delayed the development and clinical evaluation of these potentially useful materials for internal surgical procedures. However, cyanoacrylate glues are marketed actively by a number of companies for topical wound closure in accident/emergency situations and in surgical closure.
Given their ability to effectively adhere minor to moderate lacerations quickly, preempting the need for sutures that may lead to permanent scarring, and given manufacturers’ ability to promote their use, topical applications of medical adhesives have established routine clinical use. Internal applications of high strength glues, particularly cyanoacrylates will be held back until toxicity issues are addressed or avoided in the development of new chemical or biological glue types. The market for hight strength glues will nonetheless demonstrate the aggressive growth exhibited for the last few years.
Active programs are under development in three categories of new high-strength adhesive closure and securement products. The first of these comprises the application of medical grade cyanoacrylates to internal procedures for many new surgical indications and the development of procedure-enabling devices for the delicate and precise application of these strong adhesives will lead to strong market segment growth. The second category of new products will arise from improvements and new indications for existing biomaterial adhesives. The third category of new products will arise over the next decade and will include new polymer adhesives based on new chemistries.
"Worldwide Surgical Sealants, Glues and Wound Closure, 2009-2013." Published 2009, MedMarket Diligence, LLC.