Degenerative disk disease

spine-disksThe mechanics of bipedalism—walking on two legs—is often cited as a factor in the development of degenerative disease of the lumbar spine. Over a normal lifespan, humans endure microtraumas and undergo bodily changes that either alter or redistribute biomechanical forces unevenly on the lumbar region, resulting in lower back pain. The stresses and microtraumas associated with lumbar degenerative disk disease (LDDD) degrade the many structures that stabilize the spine, from the bony architecture to the intervertebral discs to the complex array of supporting muscles and ligaments. Changes to the structure of the intervertebral disc contribute to the condition. The collagen (protein) structure of the annulus fibrosis weakens over time, and the water and proteoglycan (PG) content of the disc decreases. These changes diminish the disc’s ability to handle mechanical stresses. In the end analysis, many factors, including genetic, inflammatory, traumatic, and infectious, likely work together to initiate LDDD.

The back pain associated with LDDD occurs with equal frequency among men and women. Peak incidence is around the age of 40. Estimates indicate that 175.8 million days of restricted activity each year are attributed to back pain. The condition accounts for more lost productivity than any other, with estimates running around 89 million lost work days per year. According to the National Center for Health Statistics, 14.3% of new patient visits to primary care physicians are for lower back pain, and about 13 million physician visits are made in connection with back pain complaints.

The above is a brief excerpt from the MedMarket Diligence Report #M510, "Spine Surgery Worldwide 2008-2017: Products, Technologies, Markets & Opportunities, Worldwide, 2008-2017."  This report details the complete range of products and technologies in spine surgery, including the surgical management of spine disorders, diseases and trauma, with treatments including use of grafts, demineralized bone, fusion, stabilization, disc replacement, nucleus replacement, vertebroplasty, kyphoplasty, imaging, minimally invasive surgical technologies, energy-based therapies and biologics. The report details current clinical and technology developments in the huge and rapidly growing spine surgery technologies worldwide market, with data on products in development and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity.  (See link for complete report description, table of contents, and list of exhibits.)


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