Worldwide Surgical Sealants, Glues, Wound Closure and Ant-Adhesion Markets, 2009-2013

Following is the table of contents to the MedMarket Diligence report #S175, "Worldwide Surgical Sealants, Glues, Wound Closure and Anti-Adhesion Markets, 2009-2013."  The report is described in full here.  The report may be purchased online for immediate download or may be ordered via order form.

 

Table of Contents

Executive Summary
Introduction
Demographic trends
Consumer-Driven Product Selection
Mechanisms of Tissue Repair
Commercial Imperatives
Industry Consolidation
Clinical Caseload
Market Segmentation and Dynamics
New Surgical Techniques Drive Market Opportunity
The Uses of Adjunctive Surgical Closure and Securement Products
Product Development History
Evolution of Commercial Markets for Sealants and Adhesives
Section 1:
CLINICAL NEED, CASELOAD, AND PROCEDURE VOLUME
1.1
Anatomy and Physiology of Tissue Repair
1.2
The Skin
1.3
Internal Tissues and Organs
1.4
Wound Classification and Types
1.4.1
Classification by Morphology and Severity
1.4.2
Wound Classification by Cause
1.4.3
Surgical Wounds
1.5
Caseload
1.5.1
Cardiovascular
1.5.1.1
Coronary Heart Disease
1.5.1.2
Dysfunctional Heart Valves
1.5.1.3
Peripheral Vascular Disorders
1.5.1.4
Abnormal Aortic Aneurysms
1.5.1.5
Drivers of Caseloads for Cardiac Surgery
1.5.2
Neurological
1.5.2.1
Stroke
1.5.2.2
Parkinson’s Disease
1.5.2.3
Epilepsy
1.5.2.4
Traumatic Injury
1.5.2.5
Peripheral Nerve Treatment
1.5.2.6
Neurology Drivers
1.5.3
Orthopedic
1.5.3.1
Hip Replacements
1.5.3.2
Knee Replacements
1.5.3.3
Cartilage Repair
1.5.3.4
Ligament Damage
1.5.3.5
Bone Grafting
1.5.3.6
Vertebral Disc Repair
1.5.3.7
Drivers of Orthopedic Surgery
1.5.4
Urological
1.5.4.1
Incontinence
1.5.4.2
Drivers of Urological Surgery
1.5.5
Skin
1.5.5.1
Burns
1.5.5.2
Pressure Ulcers
1.5.5.3
Diabetic Ulcers
1.5.5.4
Venous Ulcers
1.5.5.5
Plastic Surgery
1.6
The Role of Modern Sealant, Securement and Hemostatic Products in Surgery
1.6.1
Fibrin Sealants
1.6.2
High-Strength Glues
Section 2:
SCIENCE, TECHNOLOGY, DEVELOPMENT, CLINICAL AND REGULATORY CHALLENGES
2.1
Tissue Healing
2.1.1
Hemostasis
2.1.2
Proliferation and Maturation
2.1.3
Factors That Affect Healing
2.2
Product Development
2.3
Development Timelines
2.3.1
Collagen and Thrombin Combination
2.3.2
Polyethylene Glycol Polymer (PEG)
2.3.3
Albumin Cross-Linked with Glutaraldehyde
2.3.4
Delivery Systems
2.4
Cost Effectiveness
2.5
Regulatory Challenges
2.5.1
Approval Processes
2.5.2
History of Product Development
2.5.3
Regulatory Aspects
Section 3:
PRODUCTS, TECHNOLOGIES, AND FORECAST OPPORTUNITY
3.1
Overview
3.2
Development Timeline
3.3
Sutures, Staples, and Other Mechanical Closure Devices
3.3.1
Competitors and Products
3.3.2
Suppliers
3.3.3
Product Development
3.3.4
Market Analysis and Forecast
3.4
Tapes
3.4.1
Competitors and Products
3.4.2
Products in Development
3.4.3
Market Analysis and Forecast
3.5
Hemostats
3.5.1
Competitors and Products
3.5.2
Products in Development
3.5.3
Market Analysis and Forecasts
3.6
Fibrin and Other Sealant Products
3.6.1
Competitors and Products
3.6.2
Products in Development
3.6.3
Fibrin and Sealant Market and Competitive Activity
3.7
High-Strength Medical Adhesives
3.7.1
Competitors and Products
3.7.2
Products in Development
3.7.3
Market Analysis and Forecasts
3.8
Post-Surgical Adhesion Prevention
3.8.1
Competitors and Products
3.8.2
Products in Development
3.8.3
Market Analysis and Forecasts
3.9
Wound Closure and Securement Markets: Global and Regional Analysis
3.9.1
Americas
3.9.1.1
United States
3.9.1.2
Latin America
3.9.2
Japan
3.9.3
Europe
3.9.4
Rest of World
3.10
Worldwide Markets By Country and Segment
Section 4:
Company Profiles
4.1
3DM, Inc. (3D-Matrix, Ltd.)
4.2
3M
4.2.1
Products
4.2.1.1
Steri-Strip and Other Wound Closure Products
4.2.2
Financial
4.3
Abbott Vascular
4.3.1
Products
4.3.1.1
Perclose A-T, Perclose ProGlide and Prostar XL
4.3.1.2
StarClose
4.3.1.3
Chito-Seal
4.3.2
Financials
4.4
AccessClosure, Inc.
4.4.1
Product
4.4.1.1
Mynx
4.5
Adhezion Biomedical, LLC
4.6
Advanced Medical Solutions plc
4.6.1
Products
4.6.1.1
LiquiBand
4.6.2
Financials
4.7
Allerderm
4.8
Angiotech Pharmaceuticals, Inc.
4.8.1
Products
4.8.1.1
CoSeal
4.8.1.2
Vitagel
4.8.1.3
Adhibit
4.8.1.4
Quill
4.8.1.5
LOOK Sutures
4.8.1.6
Sharpoint
4.8.2
Financials
4.9
Anika Therapeutics, Inc.
4.9.1
Products
4.9.1.1
Incert-S
4.9.2
Financials
4.10
ARC Pharmaceuticals
4.10.1
Product
4.10.1.1
ARCAD
4.11
Arch Therapeutics, Inc.
4.12
ArthroCare Corporation
4.12.1
Products
4.12.1.1
MagnumWire
4.12.2
Financials
4.13
Aso LLC
4.14
Aspen Surgical Products
4.15
Atrax Medical Group
4.16
Avery Dennison
4.17
B. Braun Melsungen AG
4.17.1
Products
4.17.1.1
Histoacryl
4.17.1.2
Lysostypt
4.17.1.3
Gelita Local Hemostat
4.17.2
Financials
4.18
Bastos Viegas, s.a.
4.19
Baxter International Inc.
4.19.1
Products
4.19.1.1
Tisseel/Tissucol
4.19.1.2
FloSeal
4.19.1.3
CoSeal
4.19.1.4
TissuFleece E
4.19.1.5
ARTISS
4.19.2
Financials
4.20
Bayer HealthCare
4.21
BD (Becton, Dickinson and Company)
4.21.1
Products
4.21.1.1
Autoclip
4.22
Berlin Heart GmbH
4.22.1
Products
4.22.1.1
Gluetiss
4.23
Bernsco Surgical Supply
4.24
Biocoral Inc.
4.24.1
Products
4.24.1.1
Autologous Biological Glue
4.25
BioCore Medical Technologies, Inc.
4.26
Biogentis, Inc.
4.26.1
Products
4.26.1.1
SkinLink
4.27
Biomet Inc.
4.27.1
Product
4.27.1.1
GPS III System
4.27.1.2
Pro Osteon/BioPlex (Interpore Cross)
4.28
BIOSTER a.s.
4.29
BioSyntech Canada Inc.
4.30
BSN Medical
4.31
C.R. Bard
4.31.1
Bard Medical
4.31.2
Davol Inc.
4.31.3
Financials
4.32
Cardiovascular Sciences, Inc.
4.33
Carl Auffarth GmbH & Co. KG
4.34
Cardiva Medical, Inc.
4.35
Ceremed, Inc.
4.36
Chemence Ltd.
4.37
Chemopharma, s.a.
4.38
Cohera Medical, Inc.
4.38.1
Products
4.38.1.1
TissuGlu
4.39
Collagen Matrix, Inc.
4.39.1
Products
4.39.1.1
Porous Collagen Dental Dressings
4.39.1.2
Collatene Fibrillar Collagen Dental Dressing
4.40
Coloplast A/S
4.41
ConvaTec
4.42
Covidien Ltd.
4.42.1
Products
4.42.1.1
DuraSeal
4.42.1.2
SprayGel
4.42.1.3
Indermil (Syneture)
4.42.1.4
PleuraSeal
4.42.1.5
VascuSeal
4.42.1.6
SprayShield
4.42.2
Financials
4.43
CryoLife Inc.
4.43.1
Products
4.43.1.1
BioGlue Surgical Adhesive
4.43.1.2
BioFoam Adhesive
4.43.1.3
Hemostase MPH
4.43.2
Financials
4.44
CSIRO PhotoMedical Technologies
4.44.1
Products
4.44.1.1
PhotoSeal
4.45
CSL Behring
4.45.1
Products
4.45.1.1
Beriplast P Combi-Set (Fibrin Sealant)
4.45.1.2
Beriplex P/N, Confidex
4.45.1.3
Fibrogammin P
4.45.1.4
Haemocomplettan P
4.45.1.5
Kybernin P
4.46
CSMG Technologies, Inc.
4.46.1
Live Tissue Connect, Inc.
4.47
CuraMedical BV
4.47.1
Products
4.47.1.1
Curacel
4.47.1.2
Curacoll
4.47.1.3
Curaspon
4.48
Cypress Medical Products
4.49
Derma Sciences, Inc.
4.50
Distrex Ibérica S.A.
4.51
DuPont Applied BioSciences
4.52
Entegrion, Inc.
4.52.1
Products
4.52.1.1
Stasilon FR
4.52.1.2
Stasix
4.52.1.3
Resusix
4.53
FibroGen, Inc.
4.54
Fidia Advanced Biopolymers
4.54.1
Products
4.55
Flamel Technologies SA
4.56
Forticell Bioscience
4.56.1
Products
4.56.1.1
Fibrin MB
4.57
FzioMed Inc.
4.57.1
Products
4.57.1.1
Oxiplex/SP Gel
4.57.1.2
MediShield
4.57.1.3
Intercoat
4.57.1.4
Laresse Dermal Filler
4.58
Gelita Medical BV
4.58.1
Products
4.58.1.1
Gelita-Spon
4.58.1.2
Gelitacel
4.58.1.3
Geli Putty
4.59
GEM srl
4.60
Genzyme Biosurgery Inc.
4.60.1
Products
4.60.1.1
Sepraflm
4.60.1.2
Seprapack and Sepragel ENT
4.60.1.3
SeprameshIP
4.60.1.4
Epicel
4.60.1.5
FocalSeal
4.60.2
Financial
4.61
GluStitch, Inc.
4.61.1
Products
4.61.1.1
GluStitch
4.61.1.2
GluSeal
4.61.1.3
PeriAcryl
4.61.1.4
GluShield
4.61.1.5
GluSite
4.62
Graceduty Company Limited
4.63
GramsMed, LLC
4.64
Haemacure Corporation
4.64.1
Products
4.64.1.1
Hemaseel HMN
4.64.1.2
Hemaseel Thrombin
4.64.2
Financial Data
4.65
HAPTO Biotech Israel Ltd.
4.66
Hartmann Group
4.67
Harvest Technologies Corporation
4.68
HemCon Medical Technologies, Inc.
4.68.1
Products
4.68.1.1
HemCon Bandage
4.68.1.2
ChitoFlex
4.68.1.3
HemCon Dental Dressing
4.68.1.4
KytoStat
4.68.1.5
m•doc
4.69
Hemostasis, LLC
4.70
HyperBranch Medical Technology, Inc.
4.71
Incisive Surgical, Inc.
4.72
Innovasa Corporation
4.73
Integra Lifesciences Corporation
4.73.1
Products
4.73.2
Financials
4.74
I-Therapeutix, Inc.
4.75
Johnson & Johnson
4.75.1
Ethicon, Inc. and Ethicon Endo-Surgery, Inc.
4.75.1.1
Evicel/Quixil
4.75.1.2
Dermabond
4.75.1.3
Omnex
4.75.1.4
Gynecare Interceed
4.75.1.5
Hemostasis Products
4.75.1.6
Surgical Sutures and Skin Closures
4.75.2
DePuy Spine
4.75.3
Financials
4.76
Kaketsuken (Chemo-Sero-Therapeutic Research Institute)
4.77
Kensey Nash Corporation
4.77.1
Product
4.77.1.1
Angio-Seal
4.78
Kimberly-Clark Health Care
4.78.1
Products
4.78.1.1
InteguSeal
4.78.2
Financials
4.79
Kinetic Concepts, Inc.
4.80
King Pharmaceuticals, Inc.
4.80.1
Products
4.80.1.1
Thrombin-JMI
4.80.2
Financials
4.81
Kookbo Chemicals Co., Ltd. (KB Chem.)
4.82
Laboratoires Urgo (Urgo Medical)
4.83
Lewis Medical Supplies
4.84
LifeBond Ltd.
4.85
Lifecore Biomedical, Inc.
4.86
Lohmann & Rauscher
4.87
Marine Polymer Technologies
4.88
Medafor, Inc.
4.89
Medi Surgichem Pvt. Ltd.
4.90
MedTrade Products, Ltd.
4.91
Meyer-Haake GmbH Medical Innovations
4.92
Mölnlycke Health Care AB
4.93
Morris Innovative
4.94
Motex Healthcare Corp.
4.95
Myco Medical
4.96
NeatStitch Ltd.
4.97
Neose Technologies Inc. (Novo Nordisk)
4.98
Nycomed
4.98.1
Products
4.99
Omrix Biopharmaceuticals Inc.
4.99.1
Products
4.99.1.1
Evicel/Quixil
4.99.1.2
Fibrin Patch
4.99.1.3
Evithrom
4.99.1.4
Adhexil
4.99.2
Financials
4.100
Pac-Kit Safety Equipment
4.101
Pfizer Inc.
4.101.1
Product
4.101.1.1
Gelfoam
4.101.2
Financials
4.102
Pharming Group NV
4.102.1
Financials
4.103
Plasma Technologies, Inc.
4.104
PlasmaSeal
4.105
Pluromed, Inc.
4.106
Polyganics
4.107
Polyheal Ltd.
4.108
ProFibrix BV
4.109
Progressive Surgical, Ltd.
4.110
Protein Polymer Technologies, Inc.
4.111
Radi Medical Systems AB
4.111.1
Products
4.111.1.1
FemoSeal
4.112
Resorba Wundversorgung GmbH & Co. KG
4.113
Scapa Group plc
4.114
Scion Cardio-Vascular, Inc.
4.115
Sea Run Holdings
4.116
Seton
4.117
Smith & Nephew plc
4.118
Starch Medical, Inc.
4.118.1
Products
4.118.1.1
PerClot
4.118.1.2
StarFoam
4.118.1.3
SuperClot
4.119
Steroplast Ltd.
4.120
Sutura, Inc.
4.120.1
Products
4.120.1.1
SuperStitch
4.121
Synovis Life Technologies
4.122
SyntheMed, Inc.
4.123
Teleflex Medical
4.123.1
Products
4.123.1.1
Deknatel Sutures
4.123.1.2
Weck
4.123.2
Financial
4.124
ThermoGenesis Corporation
4.124.1
Products
4.124.1.1
CryoSeal FS System
4.124.1.2
Thrombin Processing Device (TPD)
4.125
Therus Corporation
4.126
Thrombotargets Corp.
4.126.1
Products
4.126.1.1
TT-103MH
4.127
Tissuemed Ltd.
4.127.1
Products
4.128
TraumaCure, Inc.
4.128.1
Products
4.128.1.1
WoundStat
4.129
TyRx Pharma Inc.
4.130
Vascular Solutions, Inc.
4.131
Vectura Group plc
4.131.1
Product
4.131.1.1
Adept
4.132
Vivostat A/S
4.132.1
Products
4.132.1.1
Vivostat
4.133
Z-Medica Corporation
4.134
Zimmer
4.135
ZymoGenetics, Inc.
4.135.1
Products
4.135.1.1
Recothrom
4.135.2
Financials
 
 
Appendix
List of Companies

 

List of Exhibits

Section #
Section heading
Exhibit ES-1
Recent Acquisitions in the Securement Segment
Exhibit ES-2
Introducers of New Securement Technologies to the U.S. Market
Exhibit ES-3
Definition of Surgical Closure and Securement Products
Exhibit ES-4
Incidence of Two Example Surgical Procedures with High Requirement for Adjunctive Products for Surgical Closure and Securement
Exhibit ES-5
U.S. FDA Approved Uses of Sealants, Glues, and Hemostats
Exhibit ES-6
Synthetic and Biological Sealant Competitors (Non-Fibrin Sealants)
Exhibit ES-7
Selected High-Strength Adhesive Companies and Their Strategies
Exhibit ES-8
Selected Sealant Product Companies and Their Strategies
Exhibit ES-9
Worldwide Growth in the Securement and Closure Market, 2006–2013
Exhibit 1-1
Skin Structure Illustrating Major Organelles and Skin Layers
Exhibit 1-2
Classification of Wounds by Morphology
Exhibit 1-3
Severity Classification of Wounds
Exhibit 1-4
Wound Classification by Etiology
Exhibit 1-5
Prevalence of Different Wound Types, 2008
Exhibit 1-6
Criteria for Adjunctive Use of Hemostats, Sealants, Glues and Adhesion Prevention Products in Surgery
Exhibit 1-7
Surgical Procedures with Potential for the Use of Hemostats, Sealants, Glues and Adhesion Prevention Products, Worldwide
Exhibit 1-8
Potential for Cardiovascular Applications, Prevalence of Applicable Surgical Applications
Exhibit 1-9
Potential for Neurological Applications, Prevalence of Applicable Disorders
Exhibit 1-10
Potential for Orthopedic Applications, Frequency of Major Surgical Interventions
Exhibit 1-11
Potential for Urological Applications, Prevalence of Applicable Disorders
Exhibit 1-12
Potential for Dermal Repair, Prevalence of Applicable Disorders
Exhibit 1-13
Applications of Fibrin and Other Sealants
Exhibit 1-14
Surgical Procedures Using Fibrin and Other Sealant Products (2009–2013)
Exhibit 1-15
Surgical Indications for High-Strength Glues (Europe, 2008)
Exhibit 2-1
Factors That Affect Wound Healing
Exhibit 2-2
Timescales for Development of Closure and Sealant Products
Exhibit 2-3
Variables Associated With Clinical Evaluation of Closure and Securement and Related Products
Exhibit 3-1
Manufacturers of Surgical Sutures, Staples, Clips, and Other Mechanical Closure Devices
Exhibit 3-2
Worldwide Sutures and Staples Market Forecast, 2006–2013
Exhibit 3-3
Worldwide Suture and Staples Market 2007, Share by Supplier
Exhibit 3-4
Companies Commercializing First Aid Technologies Often Used as Tapes for Closure
Exhibit 3-5
Worldwide Tapes Market Forecast, 2006-2013
Exhibit 3-6
Worldwide Tapes for Closure Market Share, 2007, by Supplier
Exhibit 3-7
Companies Commercializing Technologies in the Hemostat Category
Exhibit 3-8
Worldwide Hemostats Market Forecast, 2009–2013
Exhibit 3-9
Worldwide Hemostats Market Share, 2007, by Supplier
Exhibit 3-10
Companies Commercializing Technologies in the Sealants Category
Exhibit 3-11
Worldwide Sealants Market Forecast, 2006-2013
Exhibit 3-12
Worldwide Sealants Market Share, 2007, by Supplier
Exhibit 3-13
Companies Commercializing Cyanoacrylate-based High-Strength Medical Adhesives
Exhibit 3-14
Worldwide High-Strength Glues Market Forecast, 2006–2013
Exhibit 3-15
Worldwide High-Strength Glues Market Share 2007, by Supplier
Exhibit 3-16
Companies Commercializing Technologies in the Post-Surgical Adhesion Prevention Category
Exhibit 3-17
Worldwide Post-Operative Adhesion Prevention Market Forecast, 2006–2013
Exhibit 3-18
Worldwide Post Operative Adhesion Prevention Market Share, 2007, by Supplier
Exhibit 3-19
Size and Growth of Wound Closure and Securement Market, World and Selected Countries, 2007
Exhibit 3-20
Wound Closure Market 2007, by Product Segments, The Major American Countries
Exhibit 3-21
Wound Closure Market 2007, by Product Segments, Japan
Exhibit 3-22
Wound Closure Market 2007, by Product Segments, Major European Countries
Exhibit 3-23
Wound Closure Market 2007, by Product Segments, Rest of World
Exhibit 3-24
Growth Forecast for Closure and Securement Market, 2006–2013
Exhibit 4-1
3M, Selected Financial Data for 2007
Exhibit 4-2
Abbott Laboratories, Selected Financial Data for the First Nine Months of 2008
Exhibit 4-3
Advanced Medical Solutions’ Selected Financial Data for 2006 and 2007
Exhibit 4-4
Angiotech Pharmaceuticals’ Statement of Income for 2nd Quarter, 2008 (Ending June 30)
Exhibit 4-5
Anika Therapeutics’ Financial Results for 2006 and 2007
Exhibit 4-6
ArthroCare Corporation Financial Data
Exhibit 4-7
B. Braun Financial Data
Exhibit 4-8
Baxter International Financial Data
Exhibit 4-9
C.R. Bard, Inc. Financial Data for Nine Months Ending Sept. 30
Exhibit 4-10
Cardiovascular Sciences, Inc. Financial Data
Exhibit 4-11
Covidien, Selected Financial Data, 2007
Exhibit 4-12
CryoLife Financial Results, 2006 and 2007
Exhibit 4-13
Haemacure Corporation, Selected Financial Data
Exhibit 4-14
Integra Lifesciences, Financial Data
Exhibit 4-15
Johnson & Johnson Key Financial Data, 2006 and 2007
Exhibit 4-16
Kimberly-Clark Health Care Financial Data
Exhibit 4-17
King Pharmaceuticals Financial Data
Exhibit 4-18
Overview of Omrix’ Biosurgical Product Pipeline
Exhibit 4-19
Omrix Biopharmaceuticals Financial Data
Exhibit 4-20
Pfizer Financial Data for 2007 and 2006
Exhibit 4-21
Pharming Financial Data
Exhibit 4-22
Teleflex Inc. Financial Data
Exhibit 4-23
Vascular Solutions Financial Results
Exhibit 4-24
ZymoGenetics Financial Data, 3rd Quarter, 2008

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